Identification of new antibiotics using a microfluidic platform

Conference: MikroSystemTechnik - KONGRESS 2009
10/12/2009 - 10/14/2009 at Berlin, Germany

Proceedings: MikroSystemTechnik

Pages: 4Language: englishTyp: PDF

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Zang, E.; Martin, K. (Hans-Knöll-Institut, Jena, Germany)
Henkel, T.; Kielpinski, M. (Institut für Photonische Technologien e.V. (IPHT) Jena, Germany)
Wiesmüller, K. H. (EMC microcollections GmbH, Tübingen)

To overcome the lack of novel antimicrobial substances, we developed a microfluidic platform based on a two-phase segmented flow which enables high-throughput-screening for antibiotic substances. Core of the platform is a new microfluidic chip that allows implementation of two different screening approaches, based on actinomycetes spores and a bead-bound oligopeptide library, respectively.