Interferometric Sensor Platform for Biomolecular Interaction Analysis

Conference: Mikrosystemtechnik Kongress 2005 - Mikrosystemtechnik Kongress 2005
10/10/2005 - 10/12/2005 at Munich, Germany

Proceedings: Mikrosystemtechnik Kongress 2005

Pages: 4Language: englishTyp: PDF

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Hradetzky, David; Müller, Claas; Reinecke, Holger (Institute for Microsystem Technology (IMTEK), Laboratory of Process Technology, Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany)

This work presents a simple evanescent wave sensing system, based on an interferometric approach, suitable to meet the demands on label free sensor systems for the detection of biomolecular interactions. A highly sensitive concept for detecting key-lock interactions of biomolecules in real time was set up. It was characterized using the system as a refractometer, and the proof of concept was verified by detecting the interaction of a 21-mer DNA fragment with the immobilized counterpart. This sensor system represents a basic concept towards high throughput application.