Perforated polyimide microelectrode arrays for single-cell and tissue recording

Conference: Mikrosystemtechnik Kongress 2005 - Mikrosystemtechnik Kongress 2005
10/10/2005 - 10/12/2005 at Munich, Germany

Proceedings: Mikrosystemtechnik Kongress 2005

Pages: 4Language: englishTyp: PDF

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Stett, Alfred; Rudorf, Ralf; Stein, Bernhard; Nisch, Wilfried (NMI Natural and Medical Sciences Institute at University of Tübingen, Markwiesenstr. 55, 72770 Reutlingen, Germany)
Egert, Ulrich (Neurobiology and Biophysics, Inst. Biol. III, Albert-Ludwigs University Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany Bernstein Center for Computational Neuroscience Freiburg)
Boven, Karl-Heinz (Multi Channel Systems MCS GmbH, Aspenhau Str. 21, 72770 Reutlingen, Germany)
Gottschlich, Norbert (Greiner Bio-One GmbH, Maybachstrasse 2, 72636 Frickenhausen, Germany)

For pharmaceutical drug discovery and safety pharmacology novel micro system-based electrode arrays for electrophysiological compound testing have been fabricated. By combinating of polyimide foils structured by thinfilm technology with micro-moulded micro fluidic substrates perforated micro electrode arrays were developed. The perforation enables stable cell and tissue contacting and improves the conditions for single-cell and slice recording.