Nano- and Micro-Dialysis BioMEMS for In-Vivo Use
Conference: Mikrosystemtechnik Kongress 2005 - Mikrosystemtechnik Kongress 2005
10/10/2005 - 10/12/2005 at Munich, Germany
Proceedings: Mikrosystemtechnik Kongress 2005
Pages: 4Language: englishTyp: PDFPersonal VDE Members are entitled to a 10% discount on this title
Enderle, Barbara; Moser, Isabella; Urban, Gerald A. (IMTEK, Georges Koehler Allee 103, 79110 Freiburg, Germany)
Jobst, Gerhard (Jobst Technologies, Georges Koehler Allee 103, 79110 Freiburg, Germany)
Continuous and simultaneous monitoring of glucose and lactate in the interstitial fluid of subcutaneous adipose tissue has been realized through the combination of microdialysis with a “bioanalytical microsystem”. It provides an excellent insight into tissue metabolism, which is of interest for metabolism research and for glucose monitoring of diabetes patients. The application of a small microdialysis catheter enables a minimal invasive sampling of the probe without anesthesia. Two different monitoring systems with microdialysis sample collection are presented. With the first system, a commercially available microdialysis probe connected to a bioanalytical system we monitored 8 male volunteers for 6 hours. The correlation of the sensor signals with the CMA 600 analyzer results of all 8 experiments gave an r2= 0.834. We also found a correlation of the analyte recovery with the BMI of the volunteers. In order to overcome the limitations of commercially available microdialysis systems we used planar micro-technologies to realize a miniaturized device comprising connection fluidics integrated to a biosensor array flow cell.