Axonal blocking and injuring responses caused by asymmetric high frequency electrical stimulations of frog’s sciatic nerve
Conference: BIBE 2018 - International Conference on Biological Information and Biomedical Engineering
06/06/2018 - 06/08/2018 at Shanghai, China
Proceedings: BIBE 2018
Pages: 5Language: englishTyp: PDF
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Authors:
Zhou, Weishuai; Zhang, Xin; Chen, Weiwu; Yang, Ming; Liu, Hailong (School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China)
Sun, Lifei (Department of Electronic Engineering, Dalian Neusoft University of Information, Dalian 116032, China & College of Information Science and Technology, Dalian Maritime University, Dalian 116026, China)
Li, Sen (College of Information Science and Technology, Dalian Maritime University, Dalian 116026, P.R. China)
Guan, Shui (School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering & Research Center for the Control Engineering of Translational Precision Medicine & State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China)
Sun, Changkai (School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering & Research Center for the Control Engineering of Translational Precision Medicine & State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology & Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China)
Sun, Changsen (School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology & School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, China)
Abstract:
High frequency (HF) electrical stimulations have proven to be able to block nerve conductions, which would have widespread potential clinical applications. However, some studies demonstrated that the HF blocking stimulus of short duration of 5 s could also cause long lasting injuries to neural conductions. Further revelations of the effects of various kinds of HF stimulus on nerve’s conduction would provide more insights into the possible underlying mechanisms and directions towards designing more safe and efficacious HF waveforms. This study investigated the blocking and injuring effects of the asymmetric HF currents on neural conductions on bullfrog’s sciatic nerves. The used stimulus included the 5 s low frequency (10 Hz) pulse train to generate control and test compound action potentials (CAPs) and the 5 s HF asymmetric currents to block the CAPs conduction. The asymmetric HF waveforms were characterized by various frequencies (F=1, 2, or 5 kHz) and anode-to-cathode pulse width ratios (r=1, 2, or 3), and the first cathode pulse had a constant width of 0.05 ms. The parameters of blocking rates (BR) and injuring rates (IR) were measured to identify the possible effects. The results demonstrated that the HF currents of relatively high F (5 kHz) and low r (1 and 2) might be useful for achieving nerve conduction blockades of relatively high blocking rates and low injury rates.