Method of detecting neonatal jaundice based on dual optical path

Conference: BIBE 2019 - The Third International Conference on Biological Information and Biomedical Engineering
06/20/2019 - 06/22/2019 at Hangzhou, China

Proceedings: BIBE 2019

Pages: 5Language: englishTyp: PDF

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Zhou, Zhe; Dong, Yue-fang; Fu, Wei-wei (Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences, Suzhou, China)
Wu, Shu-Jun (School of optoelectronic engineering, Changchun University of science and Technology, Changchun, China)

According to Beer-Lambert Law, the absorption rate of light by skin tissue is related to the concentration of matter in the skin tissue and the distance of light propagation. In this paper, the study of the method of detecting bilirubin concentration in neonatal blood by dual optical path method is theoretically carried out. Compared with the traditional single optical path measurement method, the effect on the measurement results from different measurement methods and different development degree of newborn individuals can be eliminated due to the adoption of different optical path method. Through experiments and data analysis, a multivariate linear regression model between bilirubin concentration and different wavelengths and different optical path detection signals was established, and the single optical path measurement method was compared with the dual optical path method. The clinical experiment has been carried out, a term baby with jaundice and two preterm infants with jaundice were selected as experimental subjects. The measurement error of the dual path method is 3.975umol/L, which is much smaller than the single path measurement error of 15.67070umol/L. The experimental results show that the dual-path detection method effectively overcomes the impact of measurement method and individual differences of newborns. The effect is improved and the detection accuracy is improved.