Dynamics of p53 network and Eag1 channel regulated by Nutlin-3
Conference: BIBE 2019 - The Third International Conference on Biological Information and Biomedical Engineering
06/20/2019 - 06/22/2019 at Hangzhou, China
Proceedings: BIBE 2019
Pages: 4Language: englishTyp: PDFPersonal VDE Members are entitled to a 10% discount on this title
Wang, Xuzhao; Zhan, Yong; An, Hailong (State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, China & Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University ofTechnology, Tianjin, China & Key Laboratory of Molecular Biophysics of Hebei Province, School of Science, Hebei University of Technology, Tianjin, China)
Chen, Yafei; Liu, Hui; Hu, Yufeng (Key Laboratory of Molecular Biophysics of Hebei Province, School of Science, Hebei University of Technology, Tianjin, China)
The ether a go-go-1(Eag1) channel has been shown to be overexpressed in a variety of cancers. The activation of p53 by nutlin-3 induced cell growth arrest and reduced Eag1 protein level. However, the regulatory dynamics between p53 network and Eag1 is unclear. In this study, mRNA levels of p53 and Eag1 regulated by Nutlin-3 were observed in longterm. The results showed that p53 and Eag1 have strong regulatory relationships, and p53 can reduce the expression level of Eag1 in a short time, and the expression level of Eag1 changes with the concussion of p53 expression. This result will help us understand the regulation dynamics of p53 and Eag1.