Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis

Conference: BIBE 2019 - The Third International Conference on Biological Information and Biomedical Engineering
06/20/2019 - 06/22/2019 at Hangzhou, China

Proceedings: BIBE 2019

Pages: 4Language: englishTyp: PDF

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Yan, Lu; Liu, Guanwen; Jiang, Chunmei; Shao, Dongyan; Shi, Junling (Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China)
Wang, Xinglong (College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China)

Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-beta2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.