Microglia P2x4 receptor: A novel target of acupuncture treatment for neuropathic pain
Conference: BIBE 2022 - The 6th International Conference on Biological Information and Biomedical Engineering
06/19/2022 - 06/20/0202 at Virtual, China
Proceedings: BIBE 2022
Pages: 4Language: englishTyp: PDF
Authors:
Fan, Jia-Jia; Cai, Ren-Jun; Bai, Feng-Yuan; Xu, Qiu-Ling; Liu, Tao (The First Affiliated Hospital of Hainan Medical University, Haikou, China & Hainan Medical University, Haikou, China)
Abstract:
Neuropathic pain (NP) is caused by nerve damage, manifested by spontaneous pain, hyperalgesia and tactile allodynia. Meanwhile, NP can cause psychiatric disorders, such as anxiety, depression and sleep disorders. Inhibition of microglia activation and P2X4 receptor (P2X4R) has been proved were critical for neuroprotection during nerve insult. Acupuncture has been confirmed to be effective in treatment of NP without noticeable side effects. In this review, we attempt to uncover the role of microglia and P2X4R in NP, and summarize the correlation between acupuncture analgesia and microglia P2X4R. We strive to provide a new perspective for acupuncture in the treatment of NP.