An Exploration of the Association Between BMI and Inflammation Factors based on Gut Microbiota Data and Mendelian Randomization Analysis

Abstract:
Background: It is reported that the immunological dysregulation can lead to the inflammation and inflammatory diseases associated with obesity and BMI. Therefore, it is necessary to explore the potential association between BMI and inflammation- related factors. Methods: Here, we applied Mendelian Randomization methods to explore the potential association between BMI and inflammation-related factors based on gut microbiota data and National Health and Nutritional Examination Survey (NHANES) data analysis. According to the shared bacteria between inflammation-related factors and BMI, we constructed the phenotype-gut microbiota network. Results: Ruminococcaceae was found to be the most significant bacteria associated with BMI, and BMI is positive associated with white cell count and C-reactive protein (CRP). Conclusion: The present study may illuminate the potential association between BMI and inflammation-related factors.