Characteristics of Ovarian Function and Glycolipid Metabolism in Women After Autologous and Allogeneic Hematopoietic Stem Cell Transplantation

Abstract:
[objective] The clinical data, including blood glucose levels, blood lipid levels, sex hormone levels, uterine and ovarian sizes, and the characteristics of ovarian function and glucose and lipid metabolism after autologous transplantation and allograft in HSCT women were compared. [Method] A total of 35 female patients aged 15-40 who underwent hematopoietic stem cell transplantation in the First Affiliated Hospital of Kunming Medical University from January 2022 to October 2024 were included. Women with HSCT were divided into 6 patients with autologous transplantation and 29 patients with allograft transplantation. Age, sex, height, weight, medical history, fasting blood glucose (FPG), blood lipids, inflammatory factors and gynecologic ultrasound were collected. To investigate the differences and characteristics of ovarian function and glycolipid metabolism between the two groups. [Conclusion] 1. The changes of blood lipid profile were obvious after allograft transplantation compared with autologous transplantation: the overall levels of TC, FC, TG and LDL-C in the allograft transplantation group were higher than those in the autologous transplantation group, while the HDL-C level in the allograft transplantation group was lower than that in the autologous transplantation group. The dyslipidemia continued for about half a year and tended to be stable. 2. Allotransplantation has greater damage to ovarian function than autologous transplantation, resulting in significant ovarian and uterine atrophy and lower estrogen levels. 3. The inflammatory cytokines IL-1beta, IL-6 and TNF-A were higher after allograft; The inflammatory factor IL-6 was positively correlated with triglyceride level and negatively correlated with HDL-C level.