Micropatterned ultrathin polymer films for the design of live-cell microchips

Konferenz: MikroSystemTechnik - KONGRESS 2011
10.10.2011 - 12.10.2011 in Darmstadt, Deutschland

Tagungsband: MikroSystemTechnik

Seiten: 4Sprache: EnglischTyp: PDF

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Petersen, S.; Biesalski, M. (Macromolecular Chemistry and Paper Chemistry, Technische Universität Darmstadt, Germany)
Prucker, O.; Rühe, J. (Department of Microsystems Engineering, University of Freiburg, Germany)

Bioactive peptide-polymers are covalently attached on artificial surfaces using simple yet versatile photolithographical approaches. Two different strategies are presented: In the first approach, bioactive polymers are attached in monolayer configuration to glass or silicon substrates which have been modified with a photoreactive benzophenone-silane. In the second approach, a new surface coating technique is employed that allows the fast modification of polymeric substrates with a thin layer of biofunctional peptide-polymer on a partially crosslinked polymer network. The formed bioactive surface coatings are characterized with regard to the implemented topography and tested in cell adhesion assays for their ability to promote the attachment and outgrowth of living cells.