Low-Cost Fabrication of Micro Elastofluidic Systems with Integrated 3D-Shaped Electrodes for Particle-Based Separation Processes

Konferenz: MikroSystemTechnik Kongress 2021 - Kongress
08.11.2021 - 10.11.2021 in Stuttgart-Ludwigsburg, Deutschland

Tagungsband: MikroSystemTechnik Kongress 2021

Seiten: 4Sprache: EnglischTyp: PDF

Philippin, Nadine (Faculty Engineering and Business, Heilbronn University of Applied Sciences, Germany)
Frey, Alexander (Faculty of Electrical Engineering, Augsburg University of Applied Sciences, Germany)
Kuehne, Ingo (Institute for Digitalization and Electric Drives, Heilbronn University of Applied Sciences, Germany)

Microfluidic systems as emerging technology are of paramount importance for biomedical applications such as Point-of-Care-Diagnostics (POC). An immense challenge in this context is the development and equally cost-efficient fabrication of these micro systems. Embedded channels with dimensions of a few hundred nanometers up to µm scale for manipulation of particles, cells or bacteria in liquid media, are indispensable for a reliable analysis of small sample volumes. In that regard, a realisation of electrohydrodynamic (EHD) processes like dielectrophoresis (DEP) is mandatory. Beside complex physical interrelations, a novel category of microfluidic systems called micro elastofluidics expands the conglomerate of technical and medical requirements considerably. Therefore, this work focusses on a low-cost fabrication process developed beyond cleanroom environment for realization of elastic microfluidic devices. The method based on thermoplastic deformation of biocompatible polymers allows a simultaneous integration of 3D-shaped electrodes to ensure precise dielectrophoretic separation processes in case of stretching or twisting the system. Furthermore, an additional simulation premised on Finite-Element-Method (FEM) is carried out for validation. In addition, the process capability is verified by development of a first rudimentary prototype.