Improving of signal-to-noise ratio of electrophysiological recordings from explanted retinas by using perforated microelectrode arrays

Inhalt:
Microelectrode Arrays (MEA) are routinely used for electrophysiological testing of effects of pharmacological compounds on tissue samples like brain slices or retinal explants. Recordings from freshly preparated retinas are often impaired by remnants of the vitreous body on the ganglion cell side which acts as an insulating layer between electrodes and tissue. To improve the signal-to-noise ratio of the recordings perforated electrode arrays were used for drawing retina samples towards the electrodes by suction.