Integrated Microneedle Arrays and Assembly Techniques for Drug Delivery Applications

Konferenz: Smart Systems Integration 2008 - 2nd European Conference & Exhibition on Integration Issues of Miniaturized Systems - MOMS, MOEMS, ICS and Electronic Components
09.04.2008 - 10.04.2008 in Barcelona, Spain

Tagungsband: Smart Systems Integration 2008

Seiten: 3Sprache: EnglischTyp: PDF

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Mahadevan, Geetha; Sheardown, Heather (Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada)
Selvaganapathy, Ponnambalam (Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada)

There is significant interest and effort towards the development of microneedle arrays to provide a pain-free, controlled and sustained release of therapeutics to various tissues. However, current approaches involve expensive clean room processing techniques that produce microneedle arrays coupled to rigid substrates that do not conform to underlying biological tissues. In this work, we describe the design and development of 2-D arrays of hollow glass microneedles embedded in flexible PDMS (polydimethyl siloxane) substrates. This method combines the precision and accuracy of photolithographic techniques for mold construction with the economy of replica molding and confined etching techniques for low cost, high precision micromanufacturing approaches.