Effects on cells of the 44.5 kda outer membrane proteins isolated and cloned from bovine fusobacterium necrophorum (AB)

Konferenz: BIBE 2018 - International Conference on Biological Information and Biomedical Engineering
06.06.2018 - 08.06.2018 in Shanghai, China

Tagungsband: BIBE 2018

Seiten: 4Sprache: EnglischTyp: PDF

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Xu, Jing; Li, Shuyan; Gao, Han; Qi, Qiaodan; Shi, Yan; Guo, Hongyan; Zhang, Chunjing (Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar, China)

Fusobacterium (F.) necrophorum (AB), a gram-negative obligate anaerobe, a kind of conditional pathogens, is often into organism with Corynebacterium pyogenes and Staphylococcus aureus and is the main pathogens of liver abscesses in ruminants and lemierre’s syndrome and acute tonsillitis in humans. Currently, there is no effective way to resist the spread of F. necrophorum (AB).The outer membrane proteins (OMP) of F. necrophorum (AB) can be used as a novel vaccine candidate to protect against the diseases induced by F. necrophorum (AB). It is imperative to study the effects of the 44.5 kDa OMP isolated and cloned from F. necrophorum (AB) on Mouse macrophages (AnA-1). The results may be important for the prevention and treatment of the diseases from F. necrophorum (AB).