A Study on the Characterization of Skin Photoaging Using High- Frequency Quantitative Ultrasound

Inhalt:
Skin aging can be categorized into intrinsic aging and photoaging. Intrinsic aging is driven by internal biological factors and is characterized by gradual epidermal atrophy and dermal thinning. In contrast, photoaging is induced by ultraviolet (UV) radiation and results in significant skin damage, including dryness, abnormal pigmentation, and structural alterations in the dermis. However, current methods for assessing photoaging are often invasive or rely heavily on subjective evaluation. To overcome these limitations, this study established an animal photoaging model and introduced a high-frequency quantitative ultrasound-based method for evaluating skin photoaging. By analyzing the normalized power spectrum, key spectral parameters—spectral intercept (SI), spectral slope (SS), and mid-band fit (MBF)—were extracted to characterize microscopic changes in skin tissue during the photoaging process. The results demonstrate the potential of this method as a non-invasive and quantitative tool for assessing skin photoaging.